Conducting Translational Research to Improve Human Healthspan

The mission of the Integrative Physiology of Aging Laboratory is to conduct novel original research and to provide high quality research training to the next generation of research scientists.

The research of the Integrative Physiology of Aging Laboratory focuses on:

  • important changes in physiological function with aging, with a particular focus on changes in cardiovascular health involving blood pressure and vascular function;
  • modulation of cardiovascular function by changes in biological factors (e.g., estrogen status) and lifestyle behaviors (e.g., physical activity/inactivity, diet);
  • the efficacy of interventions, both lifestyle and pharmacological (including natural compounds), for reversing adverse changes in cardiovascular function with aging;
  • the integrative (systemic to molecular) biological mechanisms that mediate changes in cardiovascular health with aging and with effective interventions.
Measuring blood vessel function with ultrasound
Analyzing human endothelial cells
Breathing training for improving health
Dr. Seals delivers a talk in Sydney Australia
Analyzing endothelial function in mouse arteries

The Integrative Physiology of Aging Laboratory has been led by Dr. Douglas Seals, Distinguished Professor, for more than 35 years. During this period the Laboratory has been continuously funded by the National Institutes of Health for almost $50M in direct costs. Dr. Seals has authored over 300 publications, including many in high impact journals such as PNAS, Nature Communications and Circulation and has won several career achievement awards from the American Physiology Society (Edward F. Adolph Distinguished Lectureship and Environmental and Exercise Physiology Section Honor Award).