Recent Publications

For a complete list of publications click here.

Mahoney et al. Role of the circulating milieu in age-related arterial dysfunction: a novel ex vivo approachAm J Physiol Heart Circ Physiol, 326:H1279-H1290, 2024

Longtine et al. Female C57BL/6N mice are a viable model of aortic aging in womenAm J Physiol Heart Circ Physiol, 324:H893-H904, 2023

Freeberg et al. Dietary supplementation with NAD+-boosting compounds in humans: current knowledge and future directionsJ Gerontol A Biol Sci Med Sci, 2023

Murray et al. Aging, aerobic exercise, and cardiovascular health: barriers, alternative strategies and future directionsExp Gerontol, 173:112105, 2023

Casso AG et al. Initiation of 3,3-dimethyl-1-butanol at midlife prevents endothelial dysfunction and attenuates in vivo aortic stiffening with ageing in miceJ Physiol, 600:4633-4651, 2022

Craighead DH et al. A multi-trial, retrospective analysis of the antihypertensive effects of high-resistance, low-volume inspiratory muscle strength trainingJ Appl Physiol, 133:1001-1010, 2022

Freeberg KA et al. Nicotinamide Riboside Supplementation for Treating Elevated Systolic Blood Pressure and Arterial Stiffness in Midlife and Older AdultsFront Cardiovasc Med, 9:881703, 2022

Craighead DH et al. Time‐Efficient Inspiratory Muscle Strength Training Lowers Blood Pressure and Improves Endothelial Function, NO Bioavailability, and Oxidative Stress in Midlife/Older Adults With Above‐Normal Blood Pressure, JAHA, 10:e020980, 2021

Brunt VE et al. Gut Microbiome-Derived Metabolite Trimethylamine N-Oxide Induces Aortic Stiffening and Increases Systolic Blood Pressure With Aging in Mice and HumansHypertension, 78:499-511, 2021

Clayton ZS et al. Tumor Necrosis Factor Alpha-Mediated Inflammation and Remodeling of the Extracellular Matrix Underlies Aortic Stiffening Induced by the Common Chemotherapeutic Agent DoxorubicinHypertension, 77:1581-1590, 2021

Clayton ZS et al. Apigenin restores endothelial function by ameliorating oxidative stress, reverses aortic stiffening, and mitigates vascular inflammation with agingAJP Heart Circ, 321:H185-H196, 2021

Rossman MJ et al. Inorganic Nitrite Supplementation Improves Endothelial Function With AgingHypertension, 77:1212-1222, 2021

Professional Development Articles by Dr. Seals

The academic biomedical research laboratory as a “small business”J Appl Physiol, 131:729-742, 2021

A (baker’s) dozen tips for enhancing early-stage academic career development in biomedical researchJ Appl Physiol, 131:1505-1515, 2021

Musings on mentoring: teach your “children” wellJ Appl Physiol, 132:294-310, 2022.

To grant you an edge: part 1. General strategies for writing competitive biomedical research proposalsJ Appl Physiol, 132: 1489-1505, 2022

To grant you an edge, part 2. Tactical tips for addressing specific aspects of biomedical research proposalsJ Appl Physiol, 132:1506-1517, 2022

To grant you an edge, part 3. Considerations for writing competitive research career development proposals in the biomedical sciencesJ Appl Physiol, 132,1518-1524, 2022

Direct advice for directing an academic biomedical research laboratoryAm J Physiol Regul Integr Comp Physiol, 323:R204-R220, 2022

We, um, have, like, a problem: excessive use of fillers in scientific speechAdv Physiol Educ, 46:615-620, 2022

Talking the talk: tips for effective oral presentations in biomedical researchAm J Physiol Regul Integr Comp Physiol, 323:R496-R511, 2022

Publishing particulars: part 1. The big pictureAm J Physiol Regul Integr Comp Physiol, 324:R381-392, 2023

Publishing particulars: part 2. Tips for effective manuscript development. Am J Physiol Regul Integr Comp Physiol, 324:R393-408, 2023

Publishing particulars: part 3. General writing tips, editing, and responding to peer review. Am J Physiol Regul Integr Comp Physiol, 324:R409-424, 2023

Ponderings on peer review: part 1. Basic principlesAm J Physiol Regul Integr Comp Physiol, 325:R212-226, 2023

Ponderings on peer review: part 2. Manuscript critiquesAm J Physiol Regul Integr Comp Physiol, 325:R309-R326, 2023

Ponderings on peer review: part 3. Grant critiquesAm J Physiol Regul Integr Comp Physiol, 325:R604-R618, 2023

Scientific writing in physiology: confused/misused terms and phrasesJ Appl Physiol, 136:401-407, 2024

The complete guide to hosting a guest speakerAdv Physiol Educ, 48:215-237, 2024

Writing effective letters of recommendation in physiologyJ Appl Physiol, 136:774-785, 2024

Is it the people or the place? The remarkable 30-year period of integrative physiology research in the Carlson Gymnasium at the University of Colorado BoulderJ Appl Physiol, 137:42-50, 2024

Recent Abstracts

Yara Bernaldo De Quiros (APS, 2023) Late-life oral supplementation with apigenin mitigates loss of skeletal muscle strength and mass, exercise intolerance, and frailty with aging in mice

McKinley Coppock (APS, 2023) Sex-specific effects of mild to moderate renal dysfunction on vascular endothelial function and large elastic artery stiffness

Mary (Ashley) Darrah (APS, 2023) Cellular senescence mediates doxorubicin chemotherapy-induced aortic stiffening via circulating factors

Sanna Darvish (APS, 2023) Excess mitochondrial oxidative stress contributes to vascular endothelial dysfunction in postmenopausal women: possible protection by late-onset menopause

Kaitlin Freeberg (APS, 2023) Circulating factors in plasma from patients with COVID-19 cause endothelial cell dysfunction, oxidative stress and NAD+ depletion: prevention by nicotinamide riboside

Nathan Greenberg (APS, 2023) The short-chain fatty acid acetate improves age-associated vascular endothelial dysfunction

Holden Hemingway (APS, 2023) Passive heat therapy improves cognitive and cerebrovascular function in healthy midlife and older adults

Sophia Mahoney (APS, 2023) 25-Hydroxycholesterol reduces aortic cellular senescence and stiffness in old mice

Grace Maurer (APS, 2023) Lifelong voluntary aerobic exercise-mediated preservation of physical function is related to changes in the plasma metabolome in aged mice

Nicholas VanDongen (APS, 2023) Circulating factors from old mice directly induce endothelial dysfunction and aortic stiffening in young mouse arteries: A novel ex vivo experimental approach

Ravinandan Venkatasubramanian (APS, 2023) Senolytic administration following doxorubicin chemotherapy prevents large elastic artery stiffening and endothelial dysfunction