Publications
Recent Publications
For a complete list of publications click here.
Darvish et al. Preservation of Vascular Endothelial Function in Late-Onset Postmenopausal Women. Circulation, 2025.
Darrah and Longtine et al. The influence of a human macronutrient-matched diet on phenotypes in old mice. GeroScience, 2024.
Darvish and Mahoney et al. Socioeconomic status as a potential mediator of arterial aging in marginalized ethnic and racial groups: current understandings and future directions. J Appl Physiol, 2024
Bernaldo de Quiros et al. The bottlenose dolphin (Tursiops truncatus): A novel model for studying healthy arterial aging. Am J Physiol Heart Circ Physiol, 2024
Longtine and Greenberg et al. Oral Supplementation with the Short-Chain Fatty Acid Acetate Ameliorates Age-Related Arterial Dysfunction in Mice. Aging Biology, 2024
Mahoney et al. Role of the circulating milieu in age-related arterial dysfunction: a novel ex vivo approach. Am J Physiol Heart Circ Physiol, 326:H1279-H1290, 2024
Darvish et al. Nitrate-rich beetroot juice supplementation in midlife and older adults with renal dysfunction increases vascular endothelial function and changes the circulating milieu to improve endothelial cell nitric oxide production and oxidative stress. Am Physiol Society, 2024.
Longtine et al. Female C57BL/6N mice are a viable model of aortic aging in women. Am J Physiol Heart Circ Physiol, 324:H893-H904, 2023
Freeberg et al. Dietary supplementation with NAD+-boosting compounds in humans: current knowledge and future directions. J Gerontol A Biol Sci Med Sci, 2023
Murray et al. Aging, aerobic exercise, and cardiovascular health: barriers, alternative strategies and future directions. Exp Gerontol, 173:112105, 2023
Longtine AG et al. Initiation of 3,3-dimethyl-1-butanol at midlife prevents endothelial dysfunction and attenuates in vivo aortic stiffening with ageing in mice. J Physiol, 600:4633-4651, 2022
Craighead DH et al. A multi-trial, retrospective analysis of the antihypertensive effects of high-resistance, low-volume inspiratory muscle strength training. J Appl Physiol, 133:1001-1010, 2022
Freeberg KA et al. Nicotinamide Riboside Supplementation for Treating Elevated Systolic Blood Pressure and Arterial Stiffness in Midlife and Older Adults. Front Cardiovasc Med, 9:881703, 2022
Craighead DH et al. Time‐Efficient Inspiratory Muscle Strength Training Lowers Blood Pressure and Improves Endothelial Function, NO Bioavailability, and Oxidative Stress in Midlife/Older Adults With Above‐Normal Blood Pressure, JAHA, 10:e020980, 2021
Brunt VE et al. Gut Microbiome-Derived Metabolite Trimethylamine N-Oxide Induces Aortic Stiffening and Increases Systolic Blood Pressure With Aging in Mice and Humans. Hypertension, 78:499-511, 2021
Clayton ZS et al. Tumor Necrosis Factor Alpha-Mediated Inflammation and Remodeling of the Extracellular Matrix Underlies Aortic Stiffening Induced by the Common Chemotherapeutic Agent Doxorubicin. Hypertension, 77:1581-1590, 2021
Clayton ZS et al. Apigenin restores endothelial function by ameliorating oxidative stress, reverses aortic stiffening, and mitigates vascular inflammation with aging. AJP Heart Circ, 321:H185-H196, 2021
Rossman MJ et al. Inorganic Nitrite Supplementation Improves Endothelial Function With Aging. Hypertension, 77:1212-1222, 2021
Professional Development Articles by Dr. Seals
The academic biomedical research laboratory as a “small business”. J Appl Physiol, 131:729-742, 2021
A (baker’s) dozen tips for enhancing early-stage academic career development in biomedical research. J Appl Physiol, 131:1505-1515, 2021
Musings on mentoring: teach your “children” well. J Appl Physiol, 132:294-310, 2022.
To grant you an edge: part 1. General strategies for writing competitive biomedical research proposals. J Appl Physiol, 132: 1489-1505, 2022
To grant you an edge, part 2. Tactical tips for addressing specific aspects of biomedical research proposals. J Appl Physiol, 132:1506-1517, 2022
To grant you an edge, part 3. Considerations for writing competitive research career development proposals in the biomedical sciences. J Appl Physiol, 132,1518-1524, 2022
Direct advice for directing an academic biomedical research laboratory. Am J Physiol Regul Integr Comp Physiol, 323:R204-R220, 2022
We, um, have, like, a problem: excessive use of fillers in scientific speech. Adv Physiol Educ, 46:615-620, 2022
Talking the talk: tips for effective oral presentations in biomedical research. Am J Physiol Regul Integr Comp Physiol, 323:R496-R511, 2022
Publishing particulars: part 1. The big picture. Am J Physiol Regul Integr Comp Physiol, 324:R381-392, 2023
Publishing particulars: part 2. Tips for effective manuscript development. Am J Physiol Regul Integr Comp Physiol, 324:R393-408, 2023
Publishing particulars: part 3. General writing tips, editing, and responding to peer review. Am J Physiol Regul Integr Comp Physiol, 324:R409-424, 2023
Ponderings on peer review: part 1. Basic principles. Am J Physiol Regul Integr Comp Physiol, 325:R212-226, 2023
Ponderings on peer review: part 2. Manuscript critiques. Am J Physiol Regul Integr Comp Physiol, 325:R309-R326, 2023
Ponderings on peer review: part 3. Grant critiques. Am J Physiol Regul Integr Comp Physiol, 325:R604-R618, 2023
Scientific writing in physiology: confused/misused terms and phrases. J Appl Physiol, 136:401-407, 2024
The complete guide to hosting a guest speaker. Adv Physiol Educ, 48:215-237, 2024
Writing effective letters of recommendation in physiology. J Appl Physiol, 136:774-785, 2024
Is it the people or the place? The remarkable 30-year period of integrative physiology research in the Carlson Gymnasium at the University of Colorado Boulder. J Appl Physiol, 137:42-50, 2024
Are we soft? Importance of aligning career goals with work-life balance. J Appl Physiol, 137: 1041-1044, 2024.
Recent Abstracts
Yara Bernaldo De Quiros (APS, 2023) Late-life oral supplementation with apigenin mitigates loss of skeletal muscle strength and mass, exercise intolerance, and frailty with aging in mice
McKinley Coppock (APS, 2023) Sex-specific effects of mild to moderate renal dysfunction on vascular endothelial function and large elastic artery stiffness
Mary (Ashley) Darrah (APS, 2023) Cellular senescence mediates doxorubicin chemotherapy-induced aortic stiffening via circulating factors
Sanna Darvish (APS, 2023) Excess mitochondrial oxidative stress contributes to vascular endothelial dysfunction in postmenopausal women: possible protection by late-onset menopause
Kaitlin Freeberg (APS, 2023) Circulating factors in plasma from patients with COVID-19 cause endothelial cell dysfunction, oxidative stress and NAD+ depletion: prevention by nicotinamide riboside
Nathan Greenberg (APS, 2023) The short-chain fatty acid acetate improves age-associated vascular endothelial dysfunction
Holden Hemingway (APS, 2023) Passive heat therapy improves cognitive and cerebrovascular function in healthy midlife and older adults
Sophia Mahoney (APS, 2023) 25-Hydroxycholesterol reduces aortic cellular senescence and stiffness in old mice
Grace Maurer (APS, 2023) Lifelong voluntary aerobic exercise-mediated preservation of physical function is related to changes in the plasma metabolome in aged mice
Nicholas VanDongen (APS, 2023) Circulating factors from old mice directly induce endothelial dysfunction and aortic stiffening in young mouse arteries: A novel ex vivo experimental approach
Ravinandan Venkatasubramanian (APS, 2023) Senolytic administration following doxorubicin chemotherapy prevents large elastic artery stiffening and endothelial dysfunction